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SNCA Polyclonal Antibody

Cat No.: D-AB-10173L
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Product Name: SNCA Polyclonal Antibody
Cat No.: D-AB-10173L
Clonality: Polyclonal
Species Reactivity: Human,Mouse,Rat
Tested Applications: WB
Recommended Dilution: WB:1:500-1:1000
Format: Liquid
Source: Rabbit
Purification Method: Antigen Affinity Purification
Isotype: IgG
Conjugate: Unconjugated
Storage: Store at -20℃. Avoid freeze/thaw cycles.
Immunogen: Recombinant Human SNCA protein expressed by E.coli
Calculated Molecular Weight: 14 kDa
Observed Molecular Weight: 16 kDa
Background: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release.Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores.Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis.Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5.
Category: Primary Ab
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