Product Name: | SNCA Polyclonal Antibody |
Cat No.: | D-AB-10173L |
Clonality: | Polyclonal |
Species Reactivity: | Human,Mouse,Rat |
Tested Applications: | WB |
Recommended Dilution: | WB:1:500-1:1000 |
Format: | Liquid |
Source: | Rabbit |
Purification Method: | Antigen Affinity Purification |
Isotype: | IgG |
Conjugate: | Unconjugated |
Storage: | Store at -20℃. Avoid freeze/thaw cycles. |
Immunogen: | Recombinant Human SNCA protein expressed by E.coli |
Calculated Molecular Weight: | 14 kDa |
Observed Molecular Weight: | 16 kDa |
Background: | Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release.Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores.Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis.Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. |
Category: | Primary Ab |
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