Cat No.: D-AB-10364L

规格：

Product Name:	UMOD Polyclonal Antibody
Cat No.:	D-AB-10364L
Clonality:	Polyclonal
Species Reactivity:	Human
Tested Applications:	IHC
Recommended Dilution:	IHC 1:100-1:200
Format:	Liquid
Source:	Rabbit
Purification Method:	Antigen Affinity Purification
Isotype:	IgG
Conjugate:	Unconjugated
Storage:	Store at -20℃. Avoid freeze / thaw cycles.
Immunogen:	Recombinant Human UMOD protein expressed by E.coli
Background:	The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants.
Category:	Primary Ab

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