Product Name: | L1CAM Polyclonal Antibody |
Cat No.: | D-AB-10196L |
Clonality: | Polyclonal |
Species Reactivity: | Mouse,Rat |
Tested Applications: | WB,IHC |
Recommended Dilution: | WB 1:500-1:1000 |
Format: | Liquid |
Source: | Rabbit |
Purification Method: | Antigen Affinity Purification |
Isotype: | IgG |
Conjugate: | Unconjugated |
Storage: | Store at -20℃. Avoid freeze / thaw cycles. |
Immunogen: | Recombinant Mouse L1cam protein expressed by E.coli |
Calculated Molecular Weight: | 140kDa |
Observed Molecular Weight: | 140,220kDa |
Gene ID (NCBI): | 16728 |
Background: | The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. |
Category: | Primary Ab |
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