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SDHB Polyclonal Antibody

Cat No.: D-AB-10362L
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Product Name: SDHB Polyclonal Antibody
Cat No.: D-AB-10362L
Clonality: Polyclonal
Species Reactivity: Human
Tested Applications: IHC
Recommended Dilution: IHC 1:75-1:150
Format: Liquid
Source: Rabbit
Purification Method: Antigen Affinity Purification
Isotype: IgG
Conjugate: Unconjugated
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Immunogen: Recombinant Human SDHB protein expressed by E.coli
Gene ID (NCBI): 6390
Background: Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
Category: Primary Ab
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