Product Name: | SDHB Polyclonal Antibody |
Cat No.: | D-AB-10362L |
Clonality: | Polyclonal |
Species Reactivity: | Human |
Tested Applications: | IHC |
Recommended Dilution: | IHC 1:75-1:150 |
Format: | Liquid |
Source: | Rabbit |
Purification Method: | Antigen Affinity Purification |
Isotype: | IgG |
Conjugate: | Unconjugated |
Storage: | Store at -20℃. Avoid freeze / thaw cycles. |
Immunogen: | Recombinant Human SDHB protein expressed by E.coli |
Gene ID (NCBI): | 6390 |
Background: | Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. |
Category: | Primary Ab |
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