Product Name: | AFP Polyclonal Antibody |
Cat No.: | D-AB-10366L |
Clonality: | Polyclonal |
Species Reactivity: | Human |
Tested Applications: | IHC |
Recommended Dilution: | IHC 1:300-1:600 |
Format: | Liquid |
Source: | Rabbit |
Purification Method: | Antigen Affinity Purification |
Isotype: | IgG |
Conjugate: | Unconjugated |
Storage: | Store at -20℃. Avoid freeze / thaw cycles. |
Immunogen: | Recombinant Rat Afp protein expressed by E.coli |
Gene ID (NCBI): | 24177 |
Background: | This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. |
Category: | Primary Ab |
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