一抗
二抗
亲和凝胶及免疫磁珠
蛋白质定量试剂盒
蛋白质
规格：
查看说明书| Product Name: | DNA-RNA Hybrid Monoclonal Antibody [S9.6] |
| Cat No.: | 2112 |
| Clonality: | Monoclonal |
| Species Reactivity: | All Species |
| Tested Applications: | ELISA, IP, IF, CHIP, Dot Blot |
| Recommended Dilution: | IP: 1:50-500; IF: 1: 200 |
| Format: | Liquid |
| Source: | Mouse |
| Purification Method: | Protein A/G Purified |
| Isotype: | IgG2a |
| Conjugate: | Unconjugated |
| Storage: | Store at -20℃. Do not aliquot |
| Immunogen: | ΦX174 bacteriophage-derived synthetic DNA/RNA |
| Full Name: | DNA-RNA Hybrid |
| Background: | The DNA-RNA hybrids are a natural occurrence within eukaryotic cells and their level are high at sites of high transcriptional activity. They are non-canonical nucleic acid structures with transcriptional regulatory functions. Their presence is reported to predispose a locus to chromosomal breakage. The S9.6 monoclonal antibody recognizes DNA-RNA hybrids (also known as R-loops) and does not bind to single or double stranded DNA. The antibody has high affinity for DNARNA hybrids but also binds RNA-RNA hybrids that are AU-rich. The specificity of the antibody appears to be determined by a combination of sequence and structural dependency since Rloop sequence affects binding affinity. |
| Category: | Primary Ab |
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